Interleukin-21 (IL-21): Recombinant cytokines and receptors for further study

The cytokine IL-21 is primarily generated by CD4+ T cells and natural killer T (NKT) cells. T cell, B cell, natural killer (NK) cell, macrophage, and dendritic cell (DC) proliferation and differentiation need IL-21/IL-21 receptor (IL-21R) signaling.

The IL-21/IL-21R axis is important in viral infections, cancer, and a variety of immunological disorders, including inflammatory bowel disease (IBD), rheumatoid arthritis, and type 1 diabetes.

IL21 belongs to the γ chain cytokine family, which also includes IL2, IL4, IL7, IL9, and IL15. The JAK1 and JAK3 pathways are activated when IL21 binds to IL21R and the common chain (γc/CD132/IL2RG), which then activates the STATs (STAT1/STAT3/STAT5a/STAT5b), phosphoinositide 3-kinase (PI3K/Akt), and MAP kinase pathways.

IL2RA (CD25), IL2RB (CD122), IL4R (CD124), IL7R (CD127), and IL9R are all members of the γc family of cytokine receptors (CD129).

To aid in the research of this cytokine, Sino Biological has generated a panel of high-quality recombinant IL-21 and IL-21 receptor proteins.

Recombinant IL-21 cytokines and receptors

Sino Biological has created bioactive recombinant IL-21 cytokines from diverse species like human, mouse, rat, and canine sources.

Featured IL-21 protein

Human-IL-21 protein: 10584-HNAE

  • HPLC-verified
  • Tag-free
  • High Activity
  • High-purity

Interleukin-21 (IL-21): Recombinant cytokines and receptors for further study

Ability to induce Interferon-gamma secretion by human natural killer lymphoma NK-92 cells. Image Credit: Sino Biological Inc.

Interleukin-21 (IL-21): Recombinant cytokines and receptors for further study

>95% as determined by SEC-HPLC. Image Credit: Sino Biological Inc.

Interleukin-21 (IL-21): Recombinant cytokines and receptors for further study

Batch-to-batch Consistency. Image Credit: Sino Biological Inc.

Other recombinant IL-21 Cytokines

Table 1. Source: Sino Biological Inc.

Cat# Species Tag Expressed Host Purity Activity
50137-MNAE Mouse Native E. coli >97% Active
70016-DNAE Canine Native E. coli >97% Active
80200-R08B Rat C-His Insect Cells >90% Active
80200-RNAE Rat Native E. coli >95%  

 

Featured IL-21R protein

Human IL-21R protein | 11483-H08H

Interleukin-21 (IL-21): Recombinant cytokines and receptors for further study

Ability to inhibit IL-21 induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. Image Credit: Sino Biological Inc.

Mouse IL-21R protein | 51184-M08H

Interleukin-21 (IL-21): Recombinant cytokines and receptors for further study

Ability to inhibit mouse IL-21 induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. Image Credit: Sino Biological Inc.

Other recombinant IL-21R protein

Table 2. Source: Sino Biological Inc.

Cat# Species Tag Expressed Host Purity Activity
11483-H02H Human hFc HEK293 Cells >90% Active
51184-M02H Mouse hFc HEK293 Cells >90% Active
80189-R05H Rat mFc HEK293 Cells >90%  
80189-R08H Rat His HEK293 Cells >95% Active
90315-C02H Cynomolgus, Rhesus hFc HEK293 Cells >90% Active
90315-C08H Cynomolgus His HEK293 Cells >90%  

 

Other related proteins

  • IL‐2
  • IL-2RA (CD25)
  • IL-2RB (CD122)
  • IL-2RG (CD132)
  • IL‐4
  • IL-4R (CD124)
  • IL‐7
  • IL-7R (CD127)
  • IL‐9
  • IL-9R (CD129)
  • IL‐15

Antibodies for IL-21 cytokines and receptors

Sino Biological has created a complete panel of antibodies that can be utilized in ELISA, WB, and IHC to target IL-21 cytokines and receptors.

Table 3. Source: Sino Biological Inc.

Antigen Cat# Species Clonality Application
IL21 10584-MM01 Human Mouse MAb ELISA
IL21 10584-R145 Human Rabbit MAb ELISA
IL21 10584-T16 Human Rabbit PAb, Antigen Affinity Purified ELISA
IL21 105972-T32 Rat Rabbit PAb, Antigen Affinity Purified WB
IL21 50137-R012 Mouse Rabbit MAb ELISA
IL21 50137-RP01 Mouse Rabbit PAb ELISA
IL21 50137-T16 Mouse Rabbit PAb, Antigen Affinity Purified ELISA
IL21 50137-T48 Mouse Rabbit PAb, Antigen Affinity Purified WB, ELISA
IL21 70016-T16 Canine Rabbit PAb, Antigen Affinity Purified ELISA
IL21 80200-R101 Rat Rabbit MAb ELISA
IL21 80200-RP01 Rat Rabbit PAb ELISA
IL21 80200-T16 Rat Rabbit PAb, Antigen Affinity Purified ELISA
IL21R 11483-MM06 Human Mouse MAb ELISA
IL21R 11483-R033 Human Rabbit MAb ELISA
IL21R 11483-RP01 Human Rabbit PAb ELISA
IL21R 11483-RP02 Human Rabbit PAb, Antigen Affinity Purified ELISA
IL21R 11483-T24 Human Rabbit PAb, Antigen Affinity Purified ELISA, IHC-P
IL21R 51184-RP01 Mouse Rabbit PAb ELISA
IL21R 51184-T16 Mouse Rabbit PAb, Antigen Affinity Purified ELISA
IL21R 80189-T16 Rat Rabbit PAb, Antigen Affinity Purified ELISA
IL21R 90315-RP01 Cynomolgus Rabbit PAb ELISA
IL21R 90315-T16 Cynomolgus Rabbit PAb, Antigen Affinity Purified ELISA