Pro and anti-inflammatory cytokines in chronic inflammation

Chronic inflammation usually involves an imbalance of pro- and anti-inflammatory cytokines. Prolonged disruptions in this balance result in the development of diseases such as osteoarthritis and rheumatoid, autoimmune disorders, inflammatory bowel diseases, and cancer, emphasizing the need to decipher the mechanisms and intercalated network of cytokines involved in chronic inflammation.

Pro and anti-inflammatory cytokines in chronic inflammation

Figure 1. Cytokines involved in acute and chronic inflammatory responses (DOI:10.2741/a171). Image Credit: Sino Biological Inc.

Disturbance in levels of the key pro-inflammatory cytokines, such as IL-6, IL-1β, and TNF-α, and anti-inflammatory cytokines, such as IL-10, IL-4, and TGF-β, are mainly responsible for the development of chronic inflammation.

A number of these inflammatory mediators, such as IL-10, IL-6, TGF-β, and TNF-α, have been proven to participate in chronic inflammatory-associated tumor progression. The presence of high levels of the C-reactive protein (CRP) is one of the blood tests used to identify systemic inflammation.

Currently, cytokine therapies are used in chronic inflammatory disorder treatments but are not widely applicable. Studies are being carried out to find new and improved treatments to overcome this challenge.

Recombinant inflammatory cytokines

Sino Biological has created a comprehensive line of recombinant cytokines to aid research into chronic inflammation.

Featured recombinant cytokines

Human IL-1β protein: 10139-HNAE

Pro and anti-inflammatory cytokines in chronic inflammation

Image Credit: Sino Biological Inc.

Human TNF-α protein: 10602-HNAE

Pro and anti-inflammatory cytokines in chronic inflammation

Image Credit: Sino Biological Inc.

List of related recombinant cytokines (partial)

Table 1. Source: Sino Biological Inc.

Cat# Species Molecule Expression Host Activity Tag
67001-UNAE Feline IL-10 E. coli Active Native
10947-HNAE Human IL-10 E. coli Active Native
50245-MNAE Mouse IL-10 E. coli Active Native
62000-WNAE Sus scrofa (Pig) IL-10 E. coli Active Native
70018-DNAE Canine IL-1β E. coli Active Native
67002-UNAE Feline IL-1β E. coli Active Native
10139-HNAE Human IL-1β E. coli Active Native
GMP-10139-HNAE Human IL-1β E. coli Active Native
50101-MNAE Mouse IL-1β E. coli Active Native
65004-TNAE Rabbit IL-1β E. coli Active Native
80023-RNAE (mature form) Rat IL-1β E. coli Active Native
90010-CNAE Rhesus IL-1β E. coli Active Native
62003-WNAE Sus scrofa (Pig) IL-1β E. coli Active Native
70021-DNAE Canine IL-4 E. coli Active Native
11846-HNAE Human IL-4 E. coli Active Native
GMP-11846-HNAE Human IL-4 E. coli Active Native
51084-MNAE Mouse IL-4 E. coli Active Native
10395-HNAE Human IL-6 E. coli Active Native
GMP-10395-HNAE Human IL-6 E. coli Active Native
50136-MNAE Mouse IL-6 E. coli Active Native
80076-RNAE Rat IL-6 E. coli Active Native
90197-CNAE Rhesus IL-6 E. coli Active Native
62006-WNAE Sus scrofa (Pig) IL-6 E. coli Active Native
70087-D08H Canine TGF-β HEK293 Cells   C-His
90294-C08H Cynomolgus TGF-β HEK293 Cells Active C-His
10804-H08H Human TGF-β HEK293 Cells Active C-His
10804-HNAC Human, Rhesus, Cynomolgus, Canine TGF-β CHO Stable Cells Active Native
50698-M08H-B Mouse TGF-β HEK293 Cells   C-His
80116-RNAH Mouse, Rat TGF-β HEK293 Cells Active Native
80116-R08H Rat TGF-β HEK293 Cells   C-His
70003-DNAE Canine TNF-α E. coli Active Native
90330-CNAE-B Cynomolgus TNF-α E. coli   Native
90018-CNAE Cynomolgus, Rhesus TNF-α E. coli Active Native
60002-FNAE Ferret TNF-α E. coli Active Native
10602-HNAE Human TNF-α E. coli Active Native
GMP-10602-HNAE Human TNF-α E. coli Active Native
50349-MNAE Mouse TNF-α E. coli Active Native
80045-RNAE Rat TNF-α E. coli Active Native

 

Pro-inflammatory and anti-inflammatory cytokines

Pro-inflammatory cytokines

  • IL-1β
  • IL-6
  • IL-8
  • IL-9
  • IL-12
  • IL-15
  • IL-17
  • IL-18
  • IFN-γ
  • TNF-α
  • TNF-β

Anti-inflammatory cytokines

  • IL-4
  • IL-10
  • IL-11
  • IL-13
  • TGF-β

Diagnostics

  • CRP

Antibodies for inflammatory cytokines

Detecting inflammatory cytokines can help to identify and further delineate chronic inflammatory cascade. Sino Biological has created a panel of antibodies targeting various inflammatory cytokines with various applications in Neutralization, WB, ELISA, IHC, and FCM.

Pro and anti-inflammatory cytokines in chronic inflammation

Image Credit: Sino Biological Inc.

List of related antibodies (partial)

Table 2. Source: Sino Biological Inc.

Cat# Species Antigen Application Clonality Label
10947-MM07-B Human IL-10 ELISA Mouse MAb Biotin
10947-MM19-B Human IL-10 ELISA Mouse MAb Biotin
10947-R128-B Human IL-10 ELISA Rabbit MAb Biotin
10139-M201 Human IL-1β ELISA, IHC-P Mouse MAb  
50101-R001 Mouse IL-1β ELISA Rabbit MAb  
80023-MM71 Rat IL-1β ELISA Mouse MAb  
80023-R312 Rat IL-1β WB,ELISA Rabbit MAb  
11846-MM01-H Human IL-4 ELISA Mouse MAb HRP
11846-MM04-B Human IL-4 ELISA Mouse MAb Biotin
11846-MM04-H Human IL-4 ELISA Mouse MAb HRP
11846-R404 Human IL-4 WB Rabbit MAb  
51084-R015 Mouse IL-4 ELISA Rabbit MAb  
10395-MK23 Human IL-6 Neutralization Mouse MAb  
10395-MM10 Human IL-6 IHC-P Mouse MAb  
10395-MM19 Human IL-6 WB, IHC-P Mouse MAb  
10395-MM72-B Human IL-6 ELISA Mouse MAb Biotin
10395-MM72-H Human IL-6 ELISA Mouse MAb HRP
10395-R508 Human IL-6 Neutralization Rabbit MAb  
50136-R076 Mouse IL-6 ELISA Rabbit MAb  
80076-R007 Rat IL-6 ELISA Rabbit MAb  
10804-MM33 Human TGF-β WB Mouse MAb  
10804-R016-H Human TGF-β ELISA Rabbit MAb HRP
10602-MM01-F Human TNF-α FCM Mouse MAb FITC
10602-MM08-B Human TNF-α ELISA Mouse MAb Biotin
10602-MM08-H Human TNF-α ELISA Mouse MAb HRP
10602-MM0N1 Human TNF-α Neutralization Mouse MAb  
10602-R101-A Human TNF-α FCM Rabbit MAb APC
10602-R101-F Human TNF-α FCM Rabbit MAb FITC
10602-R101-P Human TNF-α FCM Rabbit MAb PE
10602-R10N1 Human TNF-α FCM, Neutralization Rabbit MAb  
10602-RE23-B Human TNF-α ELISA Rabbit MAb Biotin
50349-R009 Mouse TNF-α ELISA Rabbit MAb  
50349-RN023 Mouse TNF-α Neutralization Rabbit MAb  
60002-R303 Ferret TNF-α ELISA (Cap) Rabbit MAb  
70003-R001 Canine TNF-α ELISA Rabbit MAb  
80045-R141 Rat TNF-α WB, ICC/IF Rabbit MAb