Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin

Head and neck cancer (HNC) is a heterogeneous disease affecting multiple sites and cellular origins of the head and neck, including the paranasal sinuses, nasal cavity, tongue, oral cavity, larynx, pharynx, and salivary glands.

It accounts for 4% of all cancer cases in the United States and is the sixth deadliest cancer in the world. Early detection is essential for enhancing treatment outcomes, emphasizing the importance of developing new diagnostics and therapeutics.

Aside from proven biomarkers, such as MMP9, EGFR, CDKN2A, and VEGF, emerging biomarkers and drug targets like CXCR4/CD184, cIAP1, KLK6, FGFR1, XIAP, Osteonectin, BCL-2, S100A9, c-MET, FGFR3, CD44, Alpha-fetoprotein, IL-8/CXCL8, Beta-Tubulin, PFN1, and cyclin D1 provide innovative opportunities for the development of treatments options.

Sino Biological provides high-quality antibodies, recombinant proteins, and ELISA kits to assist head and neck cancer research.

Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more

Figure 1. Emerging biomarkers in head and neck cancer. Image Credit: Sino Biological Inc.

Featured recombinant HNC biomarker proteins

Sino Biological provides high-quality recombinant proteins to assist head and neck cancer research.

  • High-purity
  • Activity-validated
  • Low-endotoxin
  • Cited by researchers

Human S100A9 protein (Cat#: 11145-H08B)

Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more

Immobilized S100A8 protein can bind to human S100A9 protein. Image Credit: Sino Biological Inc.

Human BCL-2 protein (Cat#: 10195-H08E)

Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more

Immobilized human BCL2 protein can bind Mouse BCL2L1 protein (Cat#: 50012-M08E). Image Credit: Sino Biological Inc.

Human FGFR3 protein (Cat#: 16486-H02H)

Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more

Ability to inhibit FGF-acidic-dependent proliferation of Balb/c 3T3 mouse fibroblasts. Image Credit: Sino Biological Inc.

Human FGFR1 protein (Cat#: 10616-H08H)

Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more

Ability to inhibit FGF acidic-dependent proliferation of Balb/C 3T3 mouse fibroblasts. Image Credit: Sino Biological Inc.

Human CXCR4/CD184 protein (Cat#: 11325-HNAH) HPLC verified

Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more

Immobilized human CXCR4/CD184 protein-VLP can bind anti-human CXCR4/CD184 Antibody. Image Credit: Sino Biological Inc.

Human IL-8/CXCL8 protein (Cat#: 10098-HNCH2)

Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more

Immobilized human IL-8/CXCL8 can bind anti-IL-8/CXCL8 antibody (Cat#: 10098-MM18). Image Credit: Sino Biological Inc.

More recombinant HNC biomarker proteins (partial)

Table 1. Source: Sino Biological Inc.

Cat# Proteins Species Expression Host Purity Activity Tag
10929-H08H

   2 Citations

Osteonectin Human HEK293 Cells > 98 % Active His
50494-M08H

   1 Citation

Mouse HEK293 Cells > 96 % Active His
80870-R08H Rat HEK293 Cells > 90 % Active His
11145-HNAE

   3 Citations

S100A9 Human E. coli > 95 %   Native
50284-M07E

   2 Citations

Mouse E. coli > 95 %   Native
16482-H02H FGFR1 Human HEK293 Cells > 90 % Active hFc
10616-H20B1 Human Baculovirus-Insect Cells > 80 %   His & GST
16044-H02H

   1 Citation

FGFR3 Human HEK293 Cells > 95 % Active hFc
50071-M03H Mouse HEK293 Cells > 92 % Active His & hFc
90313-C02H

   1 Citation

Cynomolgus HEK293 Cells > 90 % Active hFc
10195-H08E1 BCL-2 Human E. coli > 90 %   Native
10692-H27H-B

   2 Citations

c-MET Human HEK293 Cells ≥ 90 % (SEC-HPLC) Active His & AVI
10692-H20B1 Human Baculovirus-Insect Cells > 90 % Active His & GST
50622-M02H

   11 Citations

Mouse HEK293 Cells > 92 % Active hFc
80004-R02H Rat HEK293 Cells > 95 % Active hFc
90304-C08H Cynomolgus, Rhesus HEK293 Cells ≥ 90 % (SEC-HPLC) Active His
12211-H02H

   7 Citations

CD44 Human HEK293 Cells > 90 %   hFc
12211-HNAH Human HEK293 Cells > 95 % (SEC-HPLC)   Native
10098-H01H1

   5 Citations

IL-8/CXCL8 Human HEK293 Cells > 95 % Active hFc
10098-H08Y

   2 Citations

Human Yeast > 95 % Active His
11090-H17E

   1 Citation

cIAP1 Human E. coli > 92 % Active AVI
12142-H08H KLK6 Human HEK293 Cells > 95 %   His
10606-H17E XIAP Human E. coli > 75 % Active AVI
10606-H07E1

   1 Citation

Human E. coli > 95 %   His
12177-H02H

   7 Citations

α-fetoprotein Human HEK293 Cells > 90 %   hFc
12177-H08H Human HEK293 Cells ≥ 90 % (SEC-HPLC)   His
10001-H08H

   11 Citations

EGFR Human HEK293 Cells > 90 % (SEC-HPLC) Active His
10001-H27H-B Human HEK293 Cells > 95 % (SEC-HPLC) Active His & AVI
29662-H02B

   1 Citation

Human Baculovirus-Insect Cells > 95 % Active hFc
51091-M02H Mouse HEK293 Cells > 90 % Active hFc
51091-M08H

   2 Citations

Mouse HEK293 Cells > 85 % (SEC-HPLC) Active His
70026-D08B Canine Baculovirus-Insect Cells > 90 % Active His
80100-R08H

   2 Citations

Rat HEK293 Cells > 98 % Active His
90285-C08H Cynomolgus HEK293 Cells > 90 % (SEC-HPLC) Active His
90317-K02H

   6 Citations

Rhesus HEK293 Cells > 95 % Active hFc
10008-HNAH

   1 Citation

VEGF Human HEK293 Cells > 95 % (SEC-HPLC) Active Native
10009-HNAB

   2 Citations

Human Baculovirus-Insect Cells > 95 % Active Native
11066-H27H-B

   13 Citations

Human, Cynomolgus HEK293 Cells > 95 % Active His & AVI
50159-MNAB

   7 Citations

Mouse Baculovirus-Insect Cells > 90 % Active Native
70004-DNAH

   1 Citation

Canine HEK293 Cells > 95 % Active Native
80006-RNAB

   2 Citations

Rat Baculovirus-Insect Cells > 86 % Active Native
10327-H08H

   4 Citations

MMP-9 Human HEK293 Cells > 90 % Active His
50560-MNAH

   2 Citations

Mouse HEK293 Cells > 85 %   Native
80049-R08H

   5 Citations

Rat HEK293 Cells > 85 % Active Native

 

Featured antibodies against HNC biomarkers

Sino Biological has created a panel of antibodies with multiple applications, including ELISA, ICC/IF, IHC-P, FCM, IP, and WB, to assist head and neck cancer research.

Anti-PFN1 antibody

  • Cat#: 107394-T40
  • Type: Rabbit PAb
  • Ig Type: Rabbit IgG
  • Applications: WB, IHC-P

Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more

Immunochemical staining of PFN1 in mouse colon. Image Credit: Sino Biological Inc.

Beta-Tubulin loading control antibody

  • Cat#: 100109-MM05T
  • Type: Mouse MAb
  • Ig Type: Mouse IgG2b
  • Applications: WB, IHC-P, IP, ICC/IF

Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more

Immunofluorescence staining of human Beta-Tubulin in HeLa cells. Image Credit: Sino Biological Inc.

Anti-c-MET antibody (PE)

  • Cat#: 10692-R243-P
  • Type: Rabbit MAb
  • Ig Type: Rabbit IgG
  • Applications: FCM

Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more

Profile of anti-human C-Met reactivity on HepG2 cells analyzed by flow cytometry. Image Credit: Sino Biological Inc.

CD44 matched ELISA antibody pair set

  • Cat#: SEK12211
  • Applications: Sandwich ELISA

Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin, and more

Determination of the CD44 concentration. Image Credit: Sino Biological Inc.

More featured antibodies against HNC biomarkers (partial)

Table 2. Source: Sino Biological Inc. 

Cat# Antigen Species Clonality Ig Type Application
10929-RP02 Osteonectin Human Rabbit PAb Rabbit IgG ELISA, IHC-P
10929-MM14 Human Mouse MAb Mouse IgG1 ELISA
50494-R001

   2 Citations

Mouse Rabbit MAb Rabbit IgG WB, ELISA, IP
11145-R018

   1 Citation

S100A9 Human Rabbit MAb Rabbit IgG WB, ELISA
11145-R209 Human Rabbit MAb Rabbit IgG IHC-P
11145-RP02 Human Rabbit PAb Rabbit IgG ELISA, IHC-P
11145-MM01

   1 Citation

Human Mouse MAb Mouse IgG2b FCM, ICC/IF
100621-T08 FGFR1 Human Rabbit PAb Rabbit IgG IHC-P
10616-MM09 Human Mouse MAb Mouse IgG2a IHC-P
50186-R001 Mouse Rabbit MAb Rabbit IgG ELISA
105806-T08 FGFR3 Mouse Rabbit PAb Rabbit IgG IHC-P
100550-MM07 Human Mouse MAb Mouse IgG1 IHC-P
50071-RP01 Mouse Rabbit MAb Rabbit IgG ELISA
100126-R204 BCL-2 Human Rabbit MAb Rabbit IgG IHC-P, FCM
10195-T16

   2 Citations

Human Rabbit PAb Rabbit IgG ELISA
10195-MM17 Human Mouse MAb Mouse IgG1 WB, IHC-P
10692-R243

   1 Citation

c-MET Human Rabbit MAb Rabbit IgG ELISA, FCM
100352-T32 Human Rabbit PAb Rabbit IgG WB
10692-MM02

   2 Citations

Human Mouse MAb Mouse IgG1 ELISA
12211-R001 CD44 Human Rabbit MAb Rabbit IgG ICC/IF
12211-T62 Human Rabbit PAb Rabbit IgG WB, ELISA, IHC-P, ICC/IF, IP
12211-MM01

   4 Citations

Human Mouse MAb Mouse IgG1 WB, ELISA, IHC-P, IP
12211-MM02

   1 Citation

Human Mouse MAb Mouse IgG1 FCM, ICC/IF
310268-T36 CXCR4 Human Rabbit PAb Rabbit IgG WB, IP
10098-MM18 IL-8/CXCL8 Human Mouse MAb Mouse IgG1 ELISA, ELISA (Det)
201528-T42 Human Rabbit PAb Rabbit IgG WB, IHC-P, ICC/IF
90280-R009

   1 Citation

Rhesus Rabbit MAb Rabbit IgG ELISA
201591-T02 cIAP1 Human Rabbit PAb Rabbit IgG ICC/IF
50255-T48 KLK6 Mouse Rabbit PAb Rabbit IgG WB, ELISA
10606-T26 XIAP Human Rabbit PAb Rabbit IgG ELISA, IHC-P, ICC/IF
310830-T34 Human Rabbit PAb Rabbit IgG WB, ICC/IF
12177-R003 α-fetoprotein Human Rabbit MAb Rabbit IgG WB, ELISA, IP
12177-RP01

   1 Citation

Human Rabbit PAb Rabbit IgG ELISA
12177-MM35T-A Human Mouse MAb Mouse IgG1 FCM
12177-MM33

   1 Citation

Human Mouse MAb Mouse IgG1 ELISA
104782-T34 PFN1 Human Rabbit PAb Rabbit IgG WB, ICC/IF
207508-T36

   2 Citations

cyclin D1 Human Rabbit PAb Rabbit IgG WB, IP
10204-R032 E-Cadherin Human Rabbit MAb Rabbit IgG IHC-P, ICC/IF
10204-T58 Human Rabbit PAb Rabbit IgG WB, ELISA, IHC-P, ICC/IF
10204-MM04

   7 Citations

Human Mouse MAb Mouse IgG1 ELISA (Cap), ICC/IF
10001-R021

   4 Citations

EGFR Human Rabbit MAb Rabbit IgG ELISA, ELISA (Det), ICC/IF
10001-RE01-F Human Rabbit MAb Rabbit IgG FCM
10001-REN01 Human Rabbit MAb Rabbit IgG Neutralization
10001-T48 Human Rabbit PAb Rabbit IgG WB, ELISA
10001-T24 Human Rabbit PAb Rabbit IgG ELISA, IHC-P
10001-MM01

   1 Citation

Human Mouse MAb Mouse IgG2b ELISA
10001-MM08T Human Mouse MAb Mouse IgG1 FCM, ICC/IF
10001-MM11 Human Mouse MAb Mouse IgG1 IHC-P
11066-R010

   5 Citations

VEGF Human, Cynomolgus Rabbit MAb Rabbit IgG Neutralization
11066-R105

   1 Citation

Human, Cynomolgus Rabbit MAb Rabbit IgG ELISA
10008-T26 Human Rabbit PAb Rabbit IgG ELISA, IHC-P, ICC/IF
101465-MM02

   1 Citation

Human Mouse MAb Mouse IgG3 IHC-P
10011-MM01

   1 Citation

Human Mouse MAb Mouse IgG1 FCM
10327-R043

   1 Citation

MMP-9 Human Rabbit MAb Rabbit IgG ELISA (Det)
10327-T24 Human Rabbit PAb Rabbit IgG ELISA, IHC-P
10327-MM01

   5 Citations

Human Mouse MAb Mouse IgG1 ELISA
101169-T38 CDKN2A Human Rabbit PAb Rabbit IgG WB, ICC/IF, IP